Since the meniscus is an important stabilizing structure of the knee joint and has a significant role in load-bearing and shock absorption, so the complete structural and functional reconstructions of the teared menisci should be done not only after partial meniscectomy but also post total meniscectomy. So far, animal experiments and good clinical practice have showed that the total meniscus allograft transplantation (TMAT) after total meniscectomy has partially solved the problem of structural and functional reconstructions after total meniscectomy. However, partial meniscectomy will also lead to accelerated knee degeneration, and its proportion is much higher than that of patients with total meniscectomy. Herein, the feasibility of partial meniscus allograft transplantations (PMAT) after partial meniscectomy was investigated for the first time by using the 40% posterior horn meniscectomy model of the medial meniscus in Beagle dogs, and also for the first time, TMAT group and the total meniscectomy group were used as control groups. Compared with the TMAT, the transcriptomics evaluation, scanning electron microscope observation, histological regeneration and structure, biomechanical property, inflammation environment, and the knee function post PMAT were more similar to that of normal meniscus was first reported. This study provides a PMAT scheme with clinical translational value for the complete structural and functional reconstruction of the patients with partial meniscectomy and fills the gap in the field of teared meniscus therapy on the basis of quite well clinical applications of the meniscus repair and the TMAT.
Jia-Kuo Yu, PhD supervisor, director of the Institute of Sports Medicine of Peking University, director of the Department of Sports Medicine and Knee Surgery of Peking University Third Hospital. Studied in Germany as a senior visiting scholar between 1999 and 2001. Expert enjoying the special allowance of The State Council. Chairman of Geriatric Sports Medicine Branch of Chinese Society of Gerontology and Geriatrics. Group leader of Passive Implants of Medical Device Classification Technical Committee of State Drug Administration. Vice chairman of biomaterial advanced manufacturing branch of Chinese biomaterials Society. 99 English articles were published as the first author or corresponding author. 10 monographs of the chief editor or deputy chief editor. 66 patents have been granted (including 18 invention patents), 32 patents have been converted. The total amount of conversion exceeds RMB 100 million.
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