Title: A pragmatic approach to treat lung cancer through loading theaflavin -3,3’-digallate and epigallocatechingallate in spanlastic

Abstract

When compared to other cancers, lung cancer has the highest fatality rate. If given effectively, the anti-proliferative and antioxidant properties of epigallocatechin gallate (EGCG) and Theaflavin-3,3'-digallate (TF3) can play a crucial role in treatment. To improve the chemical stability and therapeutic potential of EGCG and TF3 in the respiratory tract, a spanlastic made up of Tween-80, Span-60, and cholesterol was produced. It encapsulates EGCG and TF3 inside its vesicular structure and delivers it to cancer cells precisely. The cholesterol layer will allow for more efficient penetration, while tween-80 and span-60 will aid in deformability and lower interfacial tension, resulting in a small Z-average diameter, allowing for effective penetration between cell layers. The APIs' stability at alkaline pH (7.6) is ensured by the nano-vesicular structure, which also boosts cellular antioxidant activity and APIs' Ferric lowering antioxidant capabilities. Spanlastic has several advantages, including improved encapsulation efficiency and safe consideration by MTT testing. The lung cancer cell loses the ability of apoptosis, which can be restored using a nano-vesicular system containing EGCG and TF3, as well as the activation of several other properties such as cell arrest, activation of miR-210, suppression of cyclin D1, and inhibition of MAPK, ERK, and JAK-STAT at their maximum potential. In addition, a new type of spacer and pMDI canister has been designed to improve drug stability and delivery efficiency.

Biography

Syed Saif Imam was born in Allahabad, India, in the year 2000 and reared in New Delhi. He was interested in science and technology as a child growing up in a military school. His intense interest in medical research is most likely fueled by his family's job and the studious milieu in which he grew up. Later in his eighteens, he decided to pursue a profession in pharmacy, which he did successfully. He worked hard under the supervision of his family and college lecturers, being laser-focused on his objectives.He was praised for successfully publishing his first research study on cancer treatment using nano technology. He put in even more effort and published another study on lung cancer treatment. As if quitting was never an option in his life, he is currently working on a paper that will help women with menstrual pain. He'd always wanted to live a life where he could help and serve others. His whole purpose in life is to be there for someone.