Title: Information system with databases for studies of substances - potential medical preparations for hypoxia disorders treatment

Abstract

Hypoxia is widely spread phenomenon; it can be caused by hemorrhage, aviation accidents, technogenic environmental pollution influence, intoxication, diseases, and other reasons. Discoveries of new potential medical preparations for pharmacological treatment of these disorders are really important. Objectives of our work were studies of different substances – potential medical preparations for pharmacological corrections of hypoxic disorders, with parallel development of information system with databases for ordering of information about these substances, other information necessary for researcher-experimenter. For these works a wide spectrum of standard biochemical methods were used for pharmacological agents testing on Wistar rats in laboratory conditions; information system development using a set of information computer technologies, databases construction in parallel was done [1]. During some years we studied some such substances: non-protein factor of spleen– splenozide, derivatives of succinic acid– yackton, sufan [2, 3]. According to our experiments all studied substances could correct pathological changes in energy metabolism, the first three substances prevented reduction of anti-oxidant cell potential, caused decrease of lipid peroxidation processes. During nitrite intoxication splenozide and yackton caused visible antioxidant effects, optimization of pathologically changed metabolic processes. Later C60 fullerene possible role in hypoxia states correction was investigated as well [4]. Obtained data, other relative laboratory information were recorded in specially developed computerized working place for researcher with databases, friendly interface, “Personal mini library”, links with electronic libraries in Internet; necessary services were developed [5, 6]. For hospital such IS should be supplemented by automated work place for medical staff, developed by Dr.Aralova N.I. [6]. In conclusion, in the result of the work done the information system with databases and automated work places for researchers and medical staff were suggested, it permitted to study hypoxia effects and their correction by novel pharmacological agents in laboratory and hospital conditions.